Hey there, comfort food lover! Get ready to lose yourself in this Mac and Cheese Meatloaf Casserole—it’s like a warm hug from your favorite diner, served straight from your oven. Imagine a juicy, savory meatloaf topped with creamy, cheesy macaroni that’s gooey, golden, and oh-so-satisfying. This is the ultimate mash-up of two classics, perfect for family dinners or when you just need a little soul-soothing deliciousness. Trust me, this one’s a game-changer!

Why You’ll Love Mac and Cheese Meatloaf Casserole

This casserole isn’t just food—it’s pure comfort in every bite. Whether you’re feeding a crowd, meal-prepping for the week, or craving something hearty after a long day, this dish has you covered. Here’s why it’s a total crowd-pleaser:

Versatile: Ideal for weeknight dinners, potlucks, or even a cozy Sunday supper. It’s a one-dish wonder that fits any occasion.
Budget-Friendly: Made with pantry staples like ground beef, pasta, and cheese—no need for fancy ingredients to feel indulgent.
Quick and Easy: Straightforward steps that come together fast, even for beginner cooks. You’ll be amazed at how simple it is to make.
Customizable: Add a kick of spice, swap cheeses, or toss in veggies to make it your own. It’s super flexible!
Crowd-Pleasing: Kids and adults can’t resist the cheesy, meaty goodness. It’s a guaranteed hit at any table.

Ingredients in Mac and Cheese Meatloaf Casserole

(Note: the full ingredients list, including measurements, is provided in the recipe card directly below.)

This casserole is all about hearty, familiar ingredients that pack a flavor punch. Here’s what makes it so darn irresistible:

Ground Beef

The backbone of the meatloaf layer. It’s juicy, flavorful, and forms a sturdy base for all that cheesy goodness.

Breadcrumbs

These help bind the meatloaf, giving it structure while keeping it tender and moist.

Ketchup

A classic meatloaf ingredient that adds tangy sweetness to the meat and a glossy glaze on top.

Egg

The glue that holds the meatloaf together, ensuring it slices beautifully.

Elbow Macaroni

The perfect pasta for soaking up that creamy cheese sauce. It’s small, sturdy, and oh-so-nostalgic.

Cheddar Cheese

Sharp, melty, and cheesy perfection. It’s the star of the mac and cheese layer, bringing that gooey factor.

Milk

The base for the creamy cheese sauce, making it smooth and velvety.

Butter

A pat of butter adds richness to the cheese sauce and helps it coat the pasta evenly.

Onion

Finely diced onion adds a subtle sweetness and depth to the meatloaf.

Garlic Powder

A pinch in both the meatloaf and sauce ties all the flavors together with a savory kick.

Instructions

Let’s dive into making this epic comfort food casserole:

Preheat Your Oven

Start by preheating your oven to 375°F (190°C). This ensures even cooking and a perfectly bubbly top.

Make the Meatloaf

In a large bowl, mix ground beef, breadcrumbs, ketchup, egg, diced onion, garlic powder, and a pinch of salt. Combine until just blended—don’t overmix! Press the mixture evenly into a greased 9×13-inch baking dish.

Bake the Meatloaf Base

Pop the meatloaf layer into the oven and bake for 20 minutes. This pre-cook helps it set before adding the mac and cheese.

Cook the Macaroni

While the meatloaf bakes, boil elbow macaroni according to package instructions until al dente. Drain and set aside.

Make the Cheese Sauce

In a saucepan, melt butter over medium heat. Stir in flour to make a roux, then slowly whisk in milk. Cook until thickened, about 3-4 minutes. Add cheddar cheese and garlic powder, stirring until smooth and creamy.

Combine Mac and Cheese

Fold the cooked macaroni into the cheese sauce, making sure every noodle is coated in that glorious cheesy goodness.

Assemble the Casserole

Spread the mac and cheese evenly over the partially baked meatloaf. Drizzle a little extra ketchup on top for that classic meatloaf vibe, and sprinkle with more cheddar if you’re feeling extra.

Bake to Perfection

Bake for another 15-20 minutes, until the cheese is bubbly and golden. Let it cool for 5 minutes to set before slicing.

Serve and Enjoy

Slice into squares and serve hot. Pair with a side of veggies or just dig in—this casserole is a meal all on its own!

Nutrition Facts

Servings: 8
Calories per serving: 520

Preparation Time

Prep Time: 20 minutes
Cook Time: 40 minutes
Total Time: 1 hour

How to Serve Mac and Cheese Meatloaf Casserole

This casserole is hearty enough to shine on its own, but a few sides can make it a full-on feast. Here’s how to serve it up:

Green Salad: A crisp salad with a light vinaigrette cuts through the richness and adds freshness.
Garlic Bread: Serve with warm garlic bread to soak up any extra sauce or ketchup glaze.
Veggie Sides: Roasted broccoli, green beans, or carrots add color and balance to the meal.
Pickles: A side of tangy pickles or a pickle relish complements the savory meatloaf flavors.
As a Standalone: Slice and serve as is for a cozy, all-in-one meal that hits all the comfort food spots.
Presentation tip: Serve in a colorful baking dish and garnish with a sprinkle of fresh parsley for a pop of green.

Additional Tips

Here’s how to make this casserole even more awesome:

Prep Ahead: Make the meatloaf mixture and cheese sauce a day ahead. Store in the fridge and assemble before baking.
Spice It Up: Add a pinch of cayenne or hot sauce to the cheese sauce for a fiery twist.
Dietary Adjustments: Use ground turkey for a lighter option or gluten-free breadcrumbs and pasta for a gluten-free version.
Storage Tips: Store leftovers in an airtight container in the fridge for up to 4 days. Reheat in the oven or microwave.
Double the Batch: Make two casseroles and freeze one (unbaked) for up to 2 months. Thaw overnight before baking.

FAQ Section

Q1: Can I substitute ground beef with another meat?
A1: Totally! Ground turkey, chicken, or a beef-pork blend works well. Just adjust seasoning to taste.

Q2: Can I make this dish ahead of time?
A2: Yes! Assemble the casserole up to a day ahead, cover, and refrigerate. Bake when ready, adding 5-10 minutes to the cooking time.

Q3: How do I store leftovers?
A3: Store in an airtight container in the fridge for up to 4 days. Reheat in the oven at 350°F for best texture.

Q4: Can I freeze this dish?
A4: Yup! Freeze the unbaked or baked casserole (cooled) for up to 2 months. Thaw overnight in the fridge before reheating or baking.

Q5: What’s the best way to reheat this dish?
A5: Reheat in the oven at 350°F for 15-20 minutes, covered with foil, or microwave individual portions for 1-2 minutes.

Q6: Can I double the recipe?
A6: Definitely! Use a larger baking dish or two 9×13 pans. Double all ingredients and bake as directed.

Q7: Can I use store-bought mac and cheese?
A7: Sure! It’s a time-saver. Just spread it over the meatloaf and bake until bubbly.

Q8: Can I add vegetables to the casserole?
A8: Absolutely! Mix sautéed spinach, mushrooms, or zucchini into the meatloaf or mac and cheese for extra nutrition.

Q9: What kind of cheese can I use instead of cheddar?
A9: Try mozzarella, Monterey Jack, or a Colby blend for different cheesy vibes.

Q10: Can I make this without ketchup?
A10: Yup! Swap ketchup for BBQ sauce or a tomato paste glaze for a different flavor twist.

Conclusion

This Mac and Cheese Meatloaf Casserole is the ultimate comfort food love letter, blending two all-time favorites into one epic dish. With its savory meatloaf base and cheesy, creamy mac topping, it’s a guaranteed way to warm hearts and fill bellies. Whether you’re cooking for a family dinner or just treating yourself to some serious cozy vibes, this casserole is here to deliver. So grab your ingredients, crank up the oven, and get ready to dig into a slice of pure, cheesy bliss—you’re gonna love every bite!